2-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1) → HCID 61427365, compound

HRID 1020248Notes

Reaction equation

HRID 1020248 reaction equation
Cl.Cl[CH2:3][C:4]1[N:5]=[C:6]([NH2:9])[S:7][CH:8]=1.CCN(C(C)C)C(C)C.[CH3:19][NH:20][CH2:21][CH2:22][O:23][CH3:24]>C1COCC1>[CH3:24][O:23][CH2:22][CH2:21][N:20]([CH2:3][C:4]1[N:5]=[C:6]([NH2:9])[S:7][CH:8]=1)[CH3:19]

Participants

5

Reactant 3

HCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)2×HCID 81531DiisopropylethylamineHCID 300977(2-Methoxyethyl)(methyl)amine

Product 1

HCID 61427365HCID 61427365, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(chloromethyl)thiazol-2-amine hydrochloride (Intermediate I) (1 meq) was suspended in THF (20 ml) and DIEA (2 eq.) was added followed by addition of N-methyl-methoxyethylamine (1 eq.). The reaction was heated at reflux overnight. The reaction was concentrated by evaporation to solid residue.

Workup

  1. temperatureThe reaction was heated
  2. temperatureat reflux overnight
  3. concentrationThe reaction was concentrated by evaporation to solid residue

Sources & evidence

ORD record
ord-c228023a2937487aa86ada3c152d0636
Source dataset
uspto-grants-2014_05
Patent number
US08716320B2

Reaction notes

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