Methylamine → HCID 58055092, compound

HRID 1020270Notes

Reaction equation

HRID 1020270 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:14][N:13]=[C:12]([CH2:15]Cl)[N:11]=1)=[O:8].[CH3:20][NH2:21]>>[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:14][N:13]=[C:12]([CH2:15][NH:21][CH3:20])[N:11]=1)=[O:8]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 58055089HCID 58055089, compound2×

Product 1

HCID 58055092HCID 58055092, compound

Procedure

A solution of 1-(3-Fluorobenzyl)-3-(3-(chloromethyl)-1,2,4-thiadiazol-5-yl)urea (Intermediate XXV) and excess methyl amine (2.0M solution in THF) was heated for 15 min at 60° C. under microwave irradiation. Filtered off insolubles and removed solvent in vacuo to give title compound.

Workup

  1. filtrationFiltered off insolubles
  2. customremoved solvent in vacuo

Sources & evidence

ORD record
ord-28f8841d1e58446e8c0eb2c2bac23fec
Source dataset
uspto-grants-2014_05
Patent number
US08716320B2

Reaction notes

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