1-Phenylpiperazine → HCID 9161636, compound

HRID 1020349Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][N:3]=1.[C:11]1([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:11]1([N:17]2[CH2:22][CH2:21][N:20]([C:2]3[N:3]=[CH:4][C:5]([NH2:8])=[CH:6][CH:7]=3)[CH2:19][CH2:18]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 70961-Phenylpiperazine

HCID 783082-Chloro-5-nitropyridine

Product 1

HCID 9161636HCID 9161636, compound

Procedure

Intermediate B-12 was prepared by the general procedure for intermediate B-2, by using 2-chloro-5-nitropyridine and 1-phenylpiperazine as starting materials. LCMS (ESI) calcd for [M+1]+ 255.2. found 255.1.

Workup

customIntermediate B-12 was prepared by the general procedure for intermediate B-2

Sources & evidence

ORD record: ord-6d0224388d304463a64f5f6f8ab3c6a4
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08716312B2

Reaction notes

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