2-Chloro-5-nitropyridine → tert-Butyl 1-(5-aminopyridin-2-yl)piperidin-4-ylcarbamate

HRID 1020362Notes

Reaction equation

HRID 1020362 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13][CH2:12]1>>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:12][CH2:13][CH:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:21])[CH3:23])[CH2:15][CH2:16]2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 783082-Chloro-5-nitropyridineHCID 7238334-(N-Boc-amino)piperidine

Product 1

HCID 22557725tert-Butyl 1-(5-aminopyridin-2-yl)piperidin-4-ylcarbamate

Procedure

Intermediate B-33 was prepared by the general procedure for intermediate B-2, by using 2-chloro-5-nitropyridine and tert-butyl piperidin-4-ylcarbamate as the starting material. LCMS [M+1]+ 293.2.

Workup

  1. customIntermediate B-33 was prepared by the general procedure for intermediate B-2

Sources & evidence

ORD record
ord-c32786c8c6a84a5c9c14f4c6f8483dcb
Source dataset
uspto-grants-2014_05
Patent number
US08716312B2

Reaction notes

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