Cyclopentanemethanol → HCID 67391968, compound

HRID 1020387Notes

Reaction equation

[CH:1]1([O:7][C:8]2[O:9][C:10]([C:17]([NH:19][C:20]3[CH:21]=[N:22][C:23]([N:26]4[CH2:31][CH2:30]C(C5C=CC=CC=5)[CH2:28][CH2:27]4)=[CH:24][CH:25]=3)=[O:18])=[C:11]([C:13]([F:16])([F:15])[F:14])[N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:38]1(CO)[CH2:42][CH2:41][CH2:40][CH2:39]1>>[CH:6]1([CH2:1][O:7][C:8]2[O:9][C:10]([C:17]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:31][CH2:30][N:12]([C:8]([O:9][CH:38]5[CH2:39][CH2:40][CH2:41][CH2:42]5)=[O:7])[CH2:28][CH2:27]4)=[N:22][CH:21]=3)=[O:18])=[C:11]([C:13]([F:14])([F:16])[F:15])[N:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 77195Cyclopentanemethanol

HCID 67391158HCID 67391158, compound

Product 1

HCID 67391968HCID 67391968, compound

Procedure

Compound 287 was prepared by the general procedure for compound 284, by using intermediates A-41 and cyclopentanemethanol as starting materials. 1H NMR (500 MHz, CDCl3) δ 8.20 (d, 1H, J=2.4 Hz), 8.07 (dd, 1H, J=9.2, 2.5 Hz), 7.23 (br s, 1H), 6.68 (d, 1H, J=9.1 Hz), 5.17 (m, 1H), 4.45 (d, 2H, J=9.1 Hz), 3.64-3.52 (m, 8H), 2.45 (m, 1H), 1.92-1.84 (m, 4H), 1.80-1.56 (m, 10H), 1.42-1.32 (m, 2H); LCMS (ESI) Rt=4.13 min, calcd for [M+1]+ 552.2. found 552.3.

Sources & evidence

ORD record: ord-ddc5ff48ca324bffa636a6160dda501a
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08716312B2

Reaction notes

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