HCID 86663229, compound → HCID 49801142, compound

HRID 1020420Notes

Reaction equation

HRID 1020420 reaction equation
C([O:8][NH:9][C:10](=[O:36])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][C:22]=2[C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[C:17]1=[O:35])C1C=CC=CC=1.C(ONC(=O)CCCCCN1CC2C(=CC=CC=2C2C=CC(OC)=CC=2OC)C1=O)C1C=CC=CC=1>>[F:33][C:31]([F:32])([F:34])[C:28]1[CH:27]=[CH:26][C:25]([C:22]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:23]=2[CH2:24][N:16]([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C:10]([NH:9][OH:8])=[O:36])[C:17]3=[O:35])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 86663229HCID 86663229, compoundHCID 86663230HCID 86663230, compound

Product 1

HCID 49801142HCID 49801142, compoundYield 90%

Procedure

The procedure of the Step 4 in Example 39 was repeated except that N-(benzyloxy)-6-(1-oxo-4-(4-(trifluoromethyl)phenyl)isoindolin-2-yl)hexanamide in the step 1 of Example 44 instead of N-(benzyloxy)-6-(4-(2,4-dimethoxyphenyl)-1-oxoisoindolin-2-yl)hexanamide, was used and the reaction was performed for 25 hrs, to obtain the title compound (90%).

Sources & evidence

ORD record
ord-8653cd139de44f6aa2e825f86ac3caf8
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

Loading…