Lithium hydroxide, monohydrate → HCID 66689207, compound

HRID 1020442Notes

Reaction equation

HRID 1020442 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:5]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]C)=[O:14])=[O:6].O.[OH-].[Li+]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:5]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[O:6]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 66690331HCID 66690331, compound

Product 1

HCID 66689207HCID 66689207, compoundYield 99.6%

Procedure

The procedure of the step 2 in Example 80 was repeated except for using methyl 6-(3-methyl-4-phenyl-benzamido)hexanoate (195 mg, 0.574 mmol) instead of methyl 6-(3-bromo-2-methylbenzamido)hexanoate, and lithium hydroxide monohydrate (54 mg, 1.29 mmol) to obtain the title compound (186 mg, 99%).

Sources & evidence

ORD record
ord-6fd862fcc6184415b354dac997f827d7
Source dataset
uspto-grants-2014_05
Patent number
US08716326B2

Reaction notes

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