Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | 4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-benzenediol | HCID 13763692 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Ruthenium | HCID 23950 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86658021 | HCID 86658021 | — |
Reaction Steps
A 2,000 ml inner capacity of pressure-resistant reactor having a stirrer and a thermometer and formed of SUS316 was charged with 800 ml of diisopropyl ether, 350 g (1.27 mol) of Compound 6 and 17.5 g of 5% Ru/C (a substance containing 50% of water, produced by N.E. CHEMCAT), and then closed. Thereafter, stirring was started and then the interior of the reactor was substituted with hydrogen, followed by setting hydrogen pressure at 3.0 MPa. The temperature of the reactor was increased up to 130° C., upon which stirring was continued for 20 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08716385B2 |
|---|
| Source dataset | uspto-grants-2014_05 |
|---|
| ORD ID | ord-76da4fc76b864c29ae8d7fa893f2304b |
|---|
| Source note | uspto-grants-2014_05 |
|---|
