Diisopropyl Ether → HCID 86658021, compound

HRID 1020521Notes

Reaction equation

HRID 1020521 reaction equation
C(OC(C)C)(C)C.[F:8][C:9]([F:25])([F:24])[C:10]([C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][C:17]=1[OH:23])([OH:15])[C:11]([F:14])([F:13])[F:12].[H][H]>[Ru].O>[F:8][C:9]([F:24])([F:25])[C:10]([CH:16]1[CH2:21][CH2:20][CH:19]([OH:22])[CH2:18][CH:17]1[OH:23])([OH:15])[C:11]([F:12])([F:14])[F:13]

Participants

6

Reactant 3

HCID 7914Diisopropyl EtherHCID 137636924-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-benzenediolHCID 178418361HCID 178418361, compound2×

Product 1

HCID 86658021HCID 86658021, compound

Reagents, catalysts & solvents 2

HCID 23950RutheniumCatalystHCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A 2,000 ml inner capacity of pressure-resistant reactor having a stirrer and a thermometer and formed of SUS316 was charged with 800 ml of diisopropyl ether, 350 g (1.27 mol) of Compound 6 and 17.5 g of 5% Ru/C (a substance containing 50% of water, produced by N.E. CHEMCAT), and then closed. Thereafter, stirring was started and then the interior of the reactor was substituted with hydrogen, followed by setting hydrogen pressure at 3.0 MPa. The temperature of the reactor was increased up to 130° C., upon which stirring was continued for 20 hours.

Workup

  1. customA 2,000 ml inner capacity of pressure-resistant reactor having
  2. customa stirrer and a thermometer and formed of SUS316
  3. customproduced by N.E
  4. customCHEMCAT), and then closed
  5. stirringstirring

Sources & evidence

ORD record
ord-76da4fc76b864c29ae8d7fa893f2304b
Source dataset
uspto-grants-2014_05
Patent number
US08716385B2

Reaction notes

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