Water → HCID 66797272, compound

HRID 1020729Notes

Reaction equation

HRID 1020729 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:12])[CH:8]=2)[N:3]=1.[CH3:13][NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.O>CS(C)=O>[CH2:15]([N:14]([C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:12])[CH:8]=2)[N:3]=1)[CH3:13])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7669N-MethylbenzylamineHCID 877482,6-Dichloroquinoxaline

Product 1

HCID 66797272HCID 66797272, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2,6-Dichloroquinoxaline (0.500 g, 2.5 mmol) was dissolved in DMSO (10 mL) at RT and N-methyl-1-phenylmethanamine (1.53 g, 12.56 mmol) was added to the reaction mixture. The reaction mixture was stirred at RT for 16 hrs. After completion of reaction (checked by TLC), water (100 mL) was added to the reaction mixture and it was extracted with ethyl acetate (50 mL×3). The organic layer was washed with water (10 mL), brine (10 mL) and dried over Na2SO4. The organic layer was concentrated under vacuum to give the crude product.

Workup

  1. additionwas added to the reaction mixture and it
  2. extractionwas extracted with ethyl acetate (50 mL×3)
  3. washThe organic layer was washed with water (10 mL), brine (10 mL)
  4. dry with materialdried over Na2SO4
  5. concentrationThe organic layer was concentrated under vacuum

Sources & evidence

ORD record
ord-b806f844566f47098a575ba6558b6fef
Source dataset
uspto-grants-2014_05
Patent number
US08716473B2

Reaction notes

Loading…