HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3-Chloro-benzyl)-[6-(1H-pyrazol-4-yl)-quinoxalin-2-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[2-(3-Chloro-benzylamino)-quinoxalin-6-yl]-pyrazole-1-carboxylic acid tert-butyl ester | HCID 66797206 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3-Chloro-benzyl)-[6-(1H-pyrazol-4-yl)-quinoxalin-2-yl]-amine | HCID 49787448 | 22.3% |
Reaction Steps
To a solution of 4-[2-(3-Chloro-benzylamino)-quinoxalin-6-yl]-pyrazole-1-carboxylic acid tert-butyl ester (0.35 g, 0.80 mmol) in DCM (4 mL), was added HCl in dioxane (0.4 mL) at room temperature. After completion of the reaction, the reaction mixture was concentrated and washed with DCM (4 mL) to obtain the title compound (0.06 g, 22%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716473B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-7e3b4c60c5864efcac2214d77a03fc1d |
| Source note | uspto-grants-2014_05 |