Hydrochloric Acid → HCID 66798016, compound

HRID 1020750Notes

Reaction equation

HRID 1020750 reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)[CH:11]=1)[CH3:9])(C)(C)C.Cl>O1CCOCC1>[CH3:22][N:19]1[CH2:20][CH2:21][N:16]([C:12]2[CH:11]=[C:10]([C@H:8]([NH2:7])[CH3:9])[CH:15]=[CH:14][CH:13]=2)[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66797580HCID 66797580, compound

Product 1

HCID 66798016HCID 66798016, compoundYield 80.5%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of {(R)-1-[3-(4-Methyl-piperazin-1-yl)-phenyl]ethyl}-carbamic acid tert-butyl ester (0.6 g, 1.87 mmol) in 1,4-Dioxane (1.5 mL), was added 4N HCl(aq) (2 mL) at room temperature. The resulting mixture was heated at 50° C. for 5 h. After completion of the reaction, the reaction mixture was concentrated and washed with diethyl ether (5.0 mL) to afford the title compound (0.330 g).

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction mixture was concentrated
  3. washwashed with diethyl ether (5.0 mL)

Sources & evidence

ORD record
ord-99007a2da15245c482f653414b545da5
Source dataset
uspto-grants-2014_05
Patent number
US08716473B2

Reaction notes

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