反应详情

温度

50 °C

To a solution of {(R)-1-[3-(4-Methyl-piperazin-1-yl)-phenyl]ethyl}-carbamic acid tert-butyl ester (0.6 g, 1.87 mmol) in 1,4-Dioxane (1.5 mL), was added 4N HCl(aq) (2 mL) at room temperature. The resulting mixture was heated at 50° C. for 5 h. After completion of the reaction, the reaction mixture was concentrated and washed with diethyl ether (5.0 mL) to afford the title compound (0.330 g).

1. customAfter completion of the reaction
2. concentrationthe reaction mixture was concentrated
3. washwashed with diethyl ether (5.0 mL)