反应详情

Sodium methoxide solution (30% methanolic solution) was added to a mixture of bosentan monohydrate (10 g) in methanol (20 mL) and ethyl acetate (80 mL). The reaction mixture was stirred for 3 hours and the solid was filtered, washed with ethyl acetate (20 mL) and dried at hot air oven at 50° C. to 55° C. to obtain the title compound.

1. filtrationthe solid was filtered
2. washwashed with ethyl acetate (20 mL)
3. customdried at hot air oven at 50° C. to 55° C.