HRID1020780
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
产物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 55 °C
PROCEDURE
实验过程
Sodium methoxide solution (30% methanolic solution; 3.9 mL) was added to a mixture of bosentan monohydrate (5 g) in methanol (15 mL). Ethyl acetate (80 mL) was added to the reaction mixture. The reaction mixture was heated to 55° C. and stirred for 30 minutes at 55° C. The reaction mixture was cooled to 25° C. The reaction mixture was stirred for 1.5 hours and the solid was filtered at 10° C. to 15° C., washed with a mixture of ethyl acetate (4 mL) and methanol (1 mL). The wet material obtained was dried at hot air oven at 50° C. to 55° C. to obtain the title compound.
WORKUP
后处理
- temperatureThe reaction mixture was cooled to 25° C
- stirringThe reaction mixture was stirred for 1.5 hours
- filtrationthe solid was filtered at 10° C. to 15° C.
- washwashed with a mixture of ethyl acetate (4 mL) and methanol (1 mL)
- customThe wet material obtained
- customwas dried at hot air oven at 50° C. to 55° C.