N-Iodosuccinimide → 6-hydroxy-5-iodo-2-oxo-1H-pyridine-3-carboxamide

HRID 1020807Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020807
[OH:1][C:2]1[N:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C1C(=O)N([I:19])C(=O)C1>C(Cl)Cl>[OH:1][C:2]1[N:10]=[C:9]([OH:11])[C:8]([I:19])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Komponenten

4

Edukt 2

HCID 120273N-IodosuccinimideHCID 178513675HCID 178513675, Verbindung

Produkt 1

HCID 1785136806-hydroxy-5-iodo-2-oxo-1H-pyridine-3-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of compound 2,6-dihydroxynicotinamide (20 g, 0.13 mol) and NIS (29.2 g, 0.13 mol) in DCM (1000 mL) was stirred at r.t for 20 min. The mixture was concentrated in vacuo to afford crude compound 2,6-dihydroxy-5-iodonicotinamide. (50 g) which was used for the next step directly. 1H-NMR (400 MHz, DMSO-d6) δ (ppm) 11.04 (bs, 1H), 8.46 (s, 1H), 2.55 (s, 4H).

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6e9ae33fb99744508465198838d8cd24
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716478B2

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