Trifluoroacetic acid → HCID 57518541, compound

HRID 1020884Notes

Reaction equation

HRID 1020884 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][C@@H:12]([N:14]2[CH2:21][C:20]3[C:16](=[N:17][N:18]([S:22]([CH3:25])(=[O:24])=[O:23])[CH:19]=3)[CH2:15]2)[CH2:11][N:10]([CH2:26][C@@H:27]([OH:29])[CH3:28])[C@@H:9]1[C:30]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:31]=1[F:37])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][C@H:8]1[CH2:13][C@@H:12]([N:14]2[CH2:21][C:20]3[C:16](=[N:17][N:18]([S:22]([CH3:25])(=[O:23])=[O:24])[CH:19]=3)[CH2:15]2)[CH2:11][N:10]([CH2:26][C@@H:27]([OH:29])[CH3:28])[C@@H:9]1[C:30]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:31]=1[F:37]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131731379HCID 131731379, compound

Product 1

HCID 57518541HCID 57518541, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the product from Step A (18 mg, 0.032 mmol) was added a 1:1 mixture of dichloromethane and trifluoroacetic acid (0.5 mL). The mixture was stirred for 1 h, and the solvent removed in vacuo. The residue was purified by preparative thin layer chromatography (Analtech 1000 μm) and eluted with methanol containing 10% ammonium hydroxide in dichloromethane (10:90) to afford the title compound as a colorless solid. LC/MS 456.2 (M+1).

Workup

  1. customthe solvent removed in vacuo
  2. customThe residue was purified by preparative thin layer chromatography (Analtech 1000 μm)
  3. washeluted with methanol containing 10% ammonium hydroxide in dichloromethane (10:90)

Sources & evidence

ORD record
ord-c0c55dca862642ce932a3684ff9ea59f
Source dataset
uspto-grants-2014_05
Patent number
US08716482B2

Reaction notes

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