HCID 58946436, compound → HCID 57686422, compound

HRID 1020941Notes

Reaction equation

HRID 1020941 reaction equation
[CH3:1][O:2][C:3]([C:5]1([S:17][CH3:18])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4]>FC(F)(F)C(O)=O.ClCCl>[CH3:1][O:2][C:3]([C:5]1([S:17][CH3:18])[CH2:9][CH2:8][NH:7][CH2:6]1)=[O:4]

Participants

3

Reactant 1

HCID 58946436HCID 58946436, compound

Product 1

HCID 57686422HCID 57686422, compoundYield 217.2%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

3-Methylsulfanyl-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (2.15 gm, 8.8 mmol) was dissolved in 20 ml of 50% trifluoroacetic acid/dichloromethane and stirred for 2 hrs. The reaction mixture was evaporated to give 3.35 g of 3-Methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester 4BP as a gummy solid.

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-8558cd3469b44ba6a94ed26880965610
Source dataset
uspto-grants-2014_05
Patent number
US08716483B2

Reaction notes

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