Hydrochloric Acid → 5-(1-methyl-1H-1,2,4-triazol-3-yl)-2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine dihydrochloride

HRID 1020962Notes

Reaction equation

HRID 1020962 reaction equation
[ClH:1].[CH3:2][N:3]1[CH:7]=[N:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH:15]=3)=[N:12][CH:13]=2)=[N:4]1>O1CCOCC1.C(Cl)Cl>[ClH:1].[ClH:1].[CH3:2][N:3]1[CH:7]=[N:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH:15]=3)=[N:12][CH:13]=2)=[N:4]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58371947Tert-butyl 4-(5-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 673440865-(1-methyl-1H-1,2,4-triazol-3-yl)-2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine dihydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

4M HCl in dioxane (20 ml) was added to a solution of Tert-butyl 4-(5-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (4BX) (4 g, 11.67 mmol) in CH2Cl2 (50 ml) at room temperature. The mixture was stirred for 3 hours then solvent was evaporated yielding title product as a white solid (3.8 g).

Workup

  1. customsolvent was evaporated

Sources & evidence

ORD record
ord-14ba564c37044f01bca77ef1de068b0f
Source dataset
uspto-grants-2014_05
Patent number
US08716483B2

Reaction notes

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