反应详情

温度

55 °C

To a mixture of (S)-4-Amino-5-biphenyl-4-yl-pentanoic acid ethyl ester hydrochloride [10-a, R5=Et] (86 g) in isopropyl acetate (1 L) is added triethylamine (43 g). The mixture is then stirred at about 55° C. for 1 h and then filtered. The filtrate is heated at reflux for 24 hours. To the mixture is added saturated ammonium chloride solution and the phases are separated. The organic layer is concentrated to dryness and crystallized from isopropyl acetate to yield (S)-5-biphenyl-4-ylmethylpyrrolidin-2-one [Key Lactam (1-a, R1=H)]. Spectroscopic data agree with data provided above.

1. filtrationfiltered
2. temperatureThe filtrate is heated
3. temperatureat reflux for 24 hours
4. additionTo the mixture is added saturated ammonium chloride solution
5. customthe phases are separated
6. concentrationThe organic layer is concentrated to dryness
7. customcrystallized from isopropyl acetate