Methanol → HCID 86686220, compound

HRID 1021253Notes

Reaction equation

HRID 1021253 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][C:10]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)=[CH:9][N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.CO.[ClH:28].CCOC(C)=O>C1COCC1>[ClH:28].[ClH:28].[N:13]1([C:10]2[CH:11]=[N:12][C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)=[N:8][CH:9]=2)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 887MethanolHCID 21866389Hydrogen chloride-ethyl acetateHCID 68310416HCID 68310416, compound

Product 1

HCID 86686220HCID 86686220, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

tert-Butyl 4-[2-(morpholin-4-yl)pyrimidin-5-yl]piperazine-1-carboxylate (1.42 g) was mixed with MeOH (20 ml) and THF (20 ml), and a 4 M hydrogen chloride/EtOAc (10 ml) was added thereto, followed by stirring at room temperature overnight and then stirring for minutes under ice-cooling. The precipitated solid was collected by filtration and washed with EtOAc to obtain 4-[5-(piperazin-1-yl)pyrimidin-2-yl]morpholine dihydrochloride (1.15 g).

Workup

  1. stirringstirring for minutes under ice-
  2. temperaturecooling
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with EtOAc

Sources & evidence

ORD record
ord-137a799029964aeb841507077842b0cb
Source dataset
uspto-grants-2014_05
Patent number
US08716470B2

Reaction notes

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