反应详情

温度

90 °C

Ethyl (3-methylphenyl)acetate (5.36 g) was mixed with carbon tetrachloride (80 ml), followed by heating at 90° C. N-Bromosuccinimide (5.62 g) and α,α′-azobisisobutyronitrile (250 mg) were added thereto, followed by stirring at 90° C. for 5 hours. The reaction mixture was cooled to room temperature, and then the solid was removed by filtration. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/EtOAc) to obtain ethyl [3-(bromomethyl)phenyl]acetate (4.56 g).

1. temperatureThe reaction mixture was cooled to room temperature
2. customthe solid was removed by filtration
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe residue was purified by silica gel column chromatography (hexane/EtOAc)