Hydrochloric Acid → 1-[2-(4-amino-1-piperidinyl)ethyl]-7-fluoro-1,5-naphthyridin-2(1H)-one

HRID 102164Notes

Reaction equation

HRID 102164 reaction equation
[CH2:29]([OH:30])[CH3:31].[CH:33]([Cl:34])([Cl:35])[Cl:36].[ClH:32].[F:1][c:2]1[cH:3][n:4][c:5]2[cH:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19]3)[c:10]2[cH:11]1>>[F:1][c:2]1[cH:3][n:4][c:5]2[cH:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH2:20])[CH2:18][CH2:19]3)[c:10]2[cH:11]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6212ChloroformHCID 57815181tert-butyl (1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate

Product 1

HCID 578151991-[2-(4-amino-1-piperidinyl)ethyl]-7-fluoro-1,5-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-899d1c2da63147d0a65160d3d0b08ba9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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