反应详情

温度

30 °C

A mixture of 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole 113c (4 g, 12.9 mmol) and cyclopropanamine (7.35 g, 129 mmol) in THF (40 mL) was stirred at 30° C. overnight. After the completion of the reaction, the mixture was filtered and the solid was washed with THF (100 mL). The filtrate was concentrated under reduced pressure to give 128a (2.68 g, 99%). MS: [M+H]+ 209.

1. customAfter the completion of the reaction
2. filtrationthe mixture was filtered
3. washthe solid was washed with THF (100 mL)
4. concentrationThe filtrate was concentrated under reduced pressure