Ammonium → 4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine

HRID 102174Notes

Reaction equation

HRID 102174 reaction equation
[CH:29]([OH:30])([CH3:31])[CH3:32].[Cl:1][c:2]1[n:3][c:4]([CH2:19][CH2:20][CH:21]2[O:22][CH2:23][CH2:24][CH2:25][O:26]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10](-[c:12]1[cH:13][cH:14][c:15]([F:18])[cH:16][cH:17]1)[n:11]2.[NH4+:27].[OH-:28]>>[c:2]1([NH2:27])[n:3][c:4]([CH2:19][CH2:20][CH:21]2[O:22][CH2:23][CH2:24][CH2:25][O:26]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10](-[c:12]1[cH:13][cH:14][c:15]([F:18])[cH:16][cH:17]1)[n:11]2

Participants

5

Reactant 4

HCID 223AmmoniumHCID 961HydroxideHCID 3776IsopropanolHCID 579067552-Chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine

Product 1

HCID 249638714-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-ea2fe27ef3c946cab6e827302d3e480b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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