HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-nitropyridine → tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-nitropyridine | HCID 78240 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate | HCID 16217943 | 54.1% |
Reaction Steps
A mixture of 2-bromo-5-nitropyridine (5.0 g, 24.6 mmol), tert-butyl piperazine-1-carboxylate (13.8 g, 74.2 mmol), acetonitrile (150 mL) was stirred at reflux for 2.5 h. After the reaction was completed, the solvent was removed under reduced pressure to afford 197a as a yellow solid (4.1 g, 54%). MS-ESI: [M+H]+ 309.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716274B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-3f6de6fc0ff941999820118658d615f8 |
| Source note | uspto-grants-2014_05 |