Hydrochloric Acid → HCID 86684611, compound

HRID 1022256Notes

Reaction equation

HRID 1022256 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([NH:7]C(=O)OC(C)(C)C)[N:4]=[C:3]1[CH3:15].[ClH:16]>ClCCl.O1CCOCC1>[ClH:16].[CH3:1][N:2]1[CH:6]=[C:5]([NH2:7])[N:4]=[C:3]1[CH3:15]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 866846101434054-30-4

Product 1

HCID 86684611HCID 86684611, compoundYield 55%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 337b (1.2 g, 5.68 mmol) in dichloromethane (5.0 mL) was added 3M HCl in dioxane (5.0 mL). This mixture was stirred at room temperature for 4 h and concentrated under reduced pressure. The crude product was washed by ethyl acetate to afford 337c (450 mg, 55%) as a pale yellow solid, which was used in the next step without further purification. MS-ESI: [M+H]+ 112.2

Workup

  1. concentrationconcentrated under reduced pressure
  2. washThe crude product was washed by ethyl acetate

Sources & evidence

ORD record
ord-395a3a8bfc044ccc9541b17d61077796
Source dataset
uspto-grants-2014_05
Patent number
US08716274B2

Reaction notes

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