反应详情

温度

75 °C

A mixture of 1.08 g of 2′-benzoyl-2,2,2-trichloro-4′-trifluoromethylacetanilide, 10 ml of DMSO and 1.18 g of ammonium acetate was stirred at 75° C. for 1 hour. After cooling, 100 ml of water was added to the mixture. Precipitated crystals were collected by filtration. The collected substance was dissolved in a mixture of hexane:ethyl acetate=1:1, dehydrated using anhydrous magnesium sulfate, and then concentrated to obtain 765 mg of the titled compound. 1H NMR (CDCl3): 7.58-7.68 (3H, m), 7.75 (1H, d, J=8.8 Hz), 7.79-7.83 (2H, m), 7.93 (1H, dd, J=8.8, 1.7 Hz), 8.17 (1H, br. s), 13.37 (1H, br. s).

1. temperatureAfter cooling
2. customPrecipitated crystals
3. filtrationwere collected by filtration
4. dissolutionThe collected substance was dissolved in a mixture of hexane
5. concentrationconcentrated