Dichloromethane → 3-(3,4-dimethoxybenzyl)-7-fluoro-6-hydroxy-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione

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Reaction Steps

A mixture of 0.2 g of the compound obtained in Step 4.6, 0.036 g of ammonium formate and 0.041 g of Pd/C (10%) in 4 ml of EtOH is irradiated in a microwave field for 5 minutes at 60° C. DCM is added, the mixture is filtered and the filtrate is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a PE/EtOAc mixture from (95/5, v/v) to (0/100, v/v) to give 0.11 g of the expected product.

Provenance & Evidence