反应详情

A mixture of 0.2 g of the compound obtained in Step 4.6, 0.036 g of ammonium formate and 0.041 g of Pd/C (10%) in 4 ml of EtOH is irradiated in a microwave field for 5 minutes at 60° C. DCM is added, the mixture is filtered and the filtrate is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a PE/EtOAc mixture from (95/5, v/v) to (0/100, v/v) to give 0.11 g of the expected product.

1. customis irradiated in a microwave field for 5 minutes at 60° C
2. filtrationthe mixture is filtered
3. customthe filtrate is evaporated under reduced pressure
4. customThe residue is chromatographed on silica gel
5. washeluting with a PE/EtOAc mixture from (95/5