反应详情

A mixture of 0.57 g of the compound of Step 17.1 and 10 ml of formic acid is irradiated in a microwave field for 3 minutes at 140° C. The reaction mixture is evaporated under reduced pressure. The residue is chromatographed on an RP18 column, eluting with an ACN/water mixture from (10/90, v/v) to (50/50, v/v) to give 0.443 g of the expected product in the form of a mixture of two isomers.

1. customis irradiated in a microwave field for 3 minutes at 140° C
2. customThe reaction mixture is evaporated under reduced pressure
3. customThe residue is chromatographed on an RP18 column
4. washeluting with an ACN/water mixture from (10/90