6-(benzyloxy)-3-(3,4-dimethoxybenzyl)-1-(1-oxidotetrahydro-2H-thiopyran-4-yl)-quinazoline-2,4(1H,3H)-dione → 3-(3,4-dimethoxybenzyl)-6-hydroxy-1-(1-oxidotetrahydro-2H-thiopyran-4-yl)quinazoline-2,4(1H,3H)-dione

Participants

Reaction Steps

A mixture of 0.57 g of the compound of Step 17.1 and 10 ml of formic acid is irradiated in a microwave field for 3 minutes at 140° C. The reaction mixture is evaporated under reduced pressure. The residue is chromatographed on an RP18 column, eluting with an ACN/water mixture from (10/90, v/v) to (50/50, v/v) to give 0.443 g of the expected product in the form of a mixture of two isomers.

Provenance & Evidence