反应详情

A mixture of 0.42 g of the compound obtained in Step 18.1 and 3.66 g of formic acid is irradiated in a microwave field for 10 minutes at 180° C. The reaction mixture is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture from (100/0, v/v) to (90/10, v/v), to give the expected product.

1. customis irradiated in a microwave field for 10 minutes at 180° C
2. customThe reaction mixture is evaporated under reduced pressure
3. customThe residue is chromatographed on silica gel
4. washeluting with a DCM/MeOH mixture from (100/0