6-(benzyloxy)-3-(3,4-dimethoxybenzyl)-1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-quinazoline-2,4(1H,3H)-dione → 3-(3,4-dimethoxybenzyl)-1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-hydroxyquinazoline-2,4(1H,3H)-dione

Participants

Reaction Steps

A mixture of 0.42 g of the compound obtained in Step 18.1 and 3.66 g of formic acid is irradiated in a microwave field for 10 minutes at 180° C. The reaction mixture is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture from (100/0, v/v) to (90/10, v/v), to give the expected product.

Provenance & Evidence