反应详情

650 mg (0.94 mmol) of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(3R,4S,5S)-1-tert-butoxy-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide (Intermediate 3) were taken up in 5 ml of dichloromethane, 5 ml of trifluoroacetic acid were added and the mixture was stirred at RT overnight. The mixture was then concentrated under reduced pressure, and the residue that remained was purified by preparative HPLC. This gave 430 mg (72% of theory) of the title compound as a colourless foam.

1. concentrationThe mixture was then concentrated under reduced pressure
2. customthe residue that remained was purified by preparative HPLC