Hydrogen chloride-ethyl acetate → HCID 66975207, compound

HRID 1022534Notes

Reaction equation

HRID 1022534 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH:10]2[CH2:23][O:24][CH3:25])[CH:5]=[CH:6][C:7]=1[Cl:8].C(OCC)(=O)C.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][CH:10]2[CH2:23][O:24][CH3:25])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66975157HCID 66975157, compound

Product 1

HCID 66975207HCID 66975207, compoundYield 110%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl (6RS,7RS)-7-(3,4-dichlorophenyl)-6-(methoxymethyl)-1,4-oxazepane-4-carboxylate (58 mg) in ethyl acetate (2 mL) was added 4 N hydrogen chloride-ethyl acetate solution (3.0 mL), and the mixture was stirred at room temperature for 2 hr. The crystals obtained by concentration under reduced pressure were recrystallized from ethanol to give the title compound (26.7 mg).

Workup

  1. customThe crystals obtained by concentration under reduced pressure
  2. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-afb2d385d80e484ba93de2cd3142c0db
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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