Hydrogen chloride-ethyl acetate → HCID 66975279, compound

HRID 1022549Notes

Reaction equation

HRID 1022549 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH:10]2[CH2:23][S:24]([CH3:27])(=[O:26])=[O:25])[CH:5]=[CH:6][C:7]=1[Cl:8].C(OCC)(=O)C.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][CH:10]2[CH2:23][S:24]([CH3:27])(=[O:26])=[O:25])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66974984tert-butyl (6RS,7RS)-7-(3,4-dichlorophenyl)-6-[(methylsulfonyl)methyl]-1,4-oxazepane-4-carboxylate

Product 1

HCID 66975279HCID 66975279, compoundYield 148.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl (6RS,7RS)-7-(3,4-dichlorophenyl)-6-[(methylsulfonyl)methyl]-1,4-oxazepane-4-carboxylate (111 mg) in ethyl acetate (1 ml) was added 4 N hydrogen chloride-ethyl acetate solution (3 mL), and the mixture was stirred at room temperature for 2 hr. The crystals obtained by concentration under reduced pressure were recrystallized from ethanol-water to give the title compound (70.3 mg).

Workup

  1. customThe crystals obtained by concentration under reduced pressure
  2. customwere recrystallized from ethanol-water

Sources & evidence

ORD record
ord-1af5c83a618b40808c87bc0893c49693
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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