Hydrogen chloride-ethyl acetate → HCID 66975107, compound

HRID 1022556Notes

Reaction equation

HRID 1022556 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH:10]2[CH2:23][NH:24][S:25](=[O:28])(=[O:27])[NH2:26])[CH:5]=[CH:6][C:7]=1[Cl:8].C(OCC)(=O)C.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:15][CH2:14][CH2:13][NH:12][CH2:11][CH:10]2[CH2:23][NH:24][S:25]([NH2:26])(=[O:27])=[O:28])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66975423HCID 66975423, compound

Product 1

HCID 66975107HCID 66975107, compoundYield 118.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl (6RS,7SR)-7-(3,4-dichlorophenyl)-6-[(sulfamoylamino)methyl]-1,4-oxazepane-4-carboxylate (202 mg) in ethanol (1 mL) was added 4 N hydrogen chloride-ethyl acetate solution (3 mL), and the mixture was stirred at room temperature for 18 hr. The crystals obtained by concentration under reduced pressure were recrystallized from ethanol-water to give the title compound (103 mg).

Workup

  1. customThe crystals obtained by concentration under reduced pressure
  2. customwere recrystallized from ethanol-water

Sources & evidence

ORD record
ord-f4c147ade3554d4a924c42301c2cf6f4
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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