Dichloromethane → 4-(3,4-Difluoro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid [3-(4-fluoro-phenylamino)-1H-indazol-5-yl]-amide
Reaction equation
[CH2:47]([Cl:48])[Cl:49].[CH:38]([N:39]([CH:40]([CH3:41])[CH3:42])[CH2:43][CH3:44])([CH3:45])[CH3:46].[F:1][c:2]1[cH:3][c:4]([CH:9]2[NH:10][C:11](=[O:19])[NH:12][C:13]([CH3:18])=[C:14]2[C:15](=[O:16])[OH:17])[cH:5][cH:6][c:7]1[F:8].[F:20][c:21]1[cH:22][cH:23][c:24]([NH:27][c:28]2[n:29][nH:30][c:31]3[cH:32][cH:33][c:34]([NH2:37])[cH:35][c:36]23)[cH:25][cH:26]1>>[F:1][c:2]1[cH:3][c:4]([CH:9]2[NH:10][C:11](=[O:19])[NH:12][C:13]([CH3:18])=[C:14]2[C:15](=[O:17])[NH:37][c:34]2[cH:33][cH:32][c:31]3[nH:30][n:29][c:28]([NH:27][c:24]4[cH:23][cH:22][c:21]([F:20])[cH:26][cH:25]4)[c:36]3[cH:35]2)[cH:5][cH:6][c:7]1[F:8]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-3721038761814942a62f0f74c7720635
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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