反应详情

To a solution of tert-butyl (6R,7R)-6-(3,4-dichlorophenyl)-7-[(1S)-1,2-dihydroxyethyl]-1,4-oxazepane-4-carboxylate (450 mg) in ethanol (8 mL) was added 12 mol/kg hydrogen chloride-ethanol solution (8 mL), and the mixture was stirred at room temperature for 15 min. The solvent was evaporated under reduced pressure, and the residue was crystallized from water-ethanol-diethyl ether to give the title compound (340 mg) as colorless crystals.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was crystallized from water-ethanol-diethyl ether