Ethanol hydrochloride → (1S)-1-[(6R,7R)-6-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]ethane-1,2-diol monohydrochloride

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Reaction Steps

To a solution of tert-butyl (6R,7R)-6-(3,4-dichlorophenyl)-7-[(1S)-1,2-dihydroxyethyl]-1,4-oxazepane-4-carboxylate (450 mg) in ethanol (8 mL) was added 12 mol/kg hydrogen chloride-ethanol solution (8 mL), and the mixture was stirred at room temperature for 15 min. The solvent was evaporated under reduced pressure, and the residue was crystallized from water-ethanol-diethyl ether to give the title compound (340 mg) as colorless crystals.

Provenance & Evidence