Hydrogen chloride-ethyl acetate → HCID 66980821, compound

HRID 1022652Notes

Reaction equation

HRID 1022652 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@:9]2([CH2:23][OH:24])[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.C(OCC)(=O)C>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@@:9]2([CH2:23][OH:24])[O:15][CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66974988HCID 66974988, compound

Product 1

HCID 66980821HCID 66980821, compoundYield 157%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl (7S)-7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate (206.2 mg) in ethanol (2 mL) was added 4 N hydrogen chloride/ethyl acetate solution (2 ml), and the mixture was stirred overnight. The solvent was evaporated under reduced pressure, and the obtained crystals were recrystallized from ethanol and ethyl acetate to give the title compound (134.5 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained crystals were recrystallized from ethanol and ethyl acetate

Sources & evidence

ORD record
ord-dedf5f567b63486c8cc9828e8831ef6d
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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