Ethanol hydrochloride → HCID 86663864, compound

HRID 1022668Notes

Reaction equation

HRID 1022668 reaction equation
[C:1]([CH2:3][CH:4]1[CH:10]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[O:9][CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1)#[N:2].Cl.C(O)C>C(OCC)(=O)C>[ClH:17].[Cl:18][C:13]1[CH:12]=[C:11]([CH:10]2[O:9][CH2:8][CH2:7][NH:6][CH2:5][CH:4]2[CH2:3][C:1]#[N:2])[CH:16]=[CH:15][C:14]=1[Cl:17]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 66975209HCID 66975209, compound

Product 1

HCID 86663864HCID 86663864, compoundYield 171.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl (6RS,7RS)-6-(cyanomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (88 mg) in ethyl acetate (0.5 mL) was added 2 N hydrogen chloride-ethanol solution (3 ml), and the mixture was stirred at room temperature for 18 hr. The reaction mixture was crystallized from ethyl acetate and diisopropyl ether to give the title compound (63 mg).

Workup

  1. customThe reaction mixture was crystallized from ethyl acetate and diisopropyl ether

Sources & evidence

ORD record
ord-29556b24edff46c1b1b334ea6e308d38
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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