tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate → 5-cyclopropyl-1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-1H-pyrazole-3-carboxylic acid monohydrochloride

HRID 1022704Notes

Reaction equation

HRID 1022704 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[O:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C@H:10]2[CH2:23]OS(C)(=O)=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH:29]1([C:32]2[CH:36]=[C:35]([C:37]([O:39]CC)=[O:38])[NH:34][N:33]=2)[CH2:31][CH2:30]1>>[ClH:1].[CH:29]1([C:32]2[N:33]([CH2:23][C@H:10]3[C@H:9]([C:4]4[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=4)[O:15][CH2:14][CH2:13][NH:12][CH2:11]3)[N:34]=[C:35]([C:37]([OH:39])=[O:38])[CH:36]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 86663851tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylateHCID 178468609HCID 178468609, compound

Product 1

HCID 669762755-cyclopropyl-1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-1H-pyrazole-3-carboxylic acid monohydrochloride

Procedure

Using tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate and, ethyl 3-cyclopropyl-1H-pyrazole-5-carboxylate, and in the same manner as in Example 44, the title compound was obtained.

Sources & evidence

ORD record
ord-66c1741ffbd743f39845c70cfce15a75
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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