Hydrogen chloride-ethyl acetate → (6R,7S)-N-benzyl-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-amine monohydrochloride

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Reaction Steps

To tert-butyl (6R,7S)-6-(benzylamino)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (80 mg) was added 4.0 M hydrogen chloride-ethyl acetate solution (4 mL), and the mixture was stirred at room temperature for 1 hr. The residue obtained by concentration under reduced pressure was washed with diethyl ether to give the title compound (20 mg).

Provenance & Evidence