2-Methanesulfonylbenzoic acid → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(methylsulfonyl)benzamide monohydrochloride

HRID 1022746Notes

Reaction equation

HRID 1022746 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[CH3:25][S:26]([C:29]1[CH:37]=[CH:36][CH:35]=[CH:34][C:30]=1[C:31](O)=[O:32])(=[O:28])=[O:27]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][NH:1][C:31](=[O:32])[C:30]2[CH:34]=[CH:35][CH:36]=[CH:37][C:29]=2[S:26]([CH3:25])(=[O:28])=[O:27])=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 2843422-Methanesulfonylbenzoic acidHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

Product 1

HCID 66975691N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(methylsulfonyl)benzamide monohydrochloride

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 2-(methylsulfonyl)benzoic acid, and by a method similar to that of Example 39, the title compound was obtained.

Sources & evidence

ORD record
ord-e825d8931450460cac3c989f30c69ea6
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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