HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methanesulfonylbenzoic acid → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(methylsulfonyl)benzamide monohydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methanesulfonylbenzoic acid | HCID 284342 | — |
| Reactant | tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate | HCID 66975002 | — |
| Product | N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(methylsulfonyl)benzamide monohydrochloride | HCID 66975691 | — |
Reaction Steps
Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 2-(methylsulfonyl)benzoic acid, and by a method similar to that of Example 39, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722662B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-e825d8931450460cac3c989f30c69ea6 |
| Source note | uspto-grants-2014_05 |