4-Chlorobutyryl chloride → HCID 66976296, compound

HRID 1022759Notes

Reaction equation

HRID 1022759 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.Cl[CH2:26][CH2:27][CH2:28][C:29](Cl)=[O:30]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][N:1]2[CH2:26][CH2:27][CH2:28][C:29]2=[O:30])=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 783704-Chlorobutyryl chlorideHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

Product 1

HCID 66976296HCID 66976296, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 4-chlorobutanoyl chloride, and by a method similar to that of Example 363, steps A and B and Example 39, step B, the title compound was obtained.

Sources & evidence

ORD record
ord-d32e85bcd6dc4ade86d8102f016f4576
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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