5-Chlorovaleryl chloride → HCID 66975764, compound

HRID 1022760Notes

Reaction equation

HRID 1022760 reaction equation
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.Cl[CH2:26][CH2:27][CH2:28][CH2:29][C:30](Cl)=[O:31]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][N:1]2[CH2:26][CH2:27][CH2:28][CH2:29][C:30]2=[O:31])=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 740895-Chlorovaleryl chlorideHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

Product 1

HCID 66975764HCID 66975764, compound

Procedure

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 5-chloropentanoyl chloride, and by a method similar to that of Example 363, steps A and B and Example 39, step B, the title compound was obtained.

Sources & evidence

ORD record
ord-2bd45d79561f4c869169bfb0ca25752f
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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