Water → HCID 66976104, compound

HRID 1022780Notes

Reaction equation

HRID 1022780 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:11]2[CH:17]([CH2:18][O:19][CH2:20][C:21]([O:23]CC)=[O:22])[O:16][CH2:15][CH2:14][N:13]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:12]2)[CH:7]=[CH:8][C:9]=1[Cl:10].O>C(O)C>[C:29]([O:28][C:26]([N:13]1[CH2:12][CH:11]([C:6]2[CH:7]=[CH:8][C:9]([Cl:10])=[C:4]([Cl:3])[CH:5]=2)[CH:17]([CH2:18][O:19][CH2:20][C:21]([OH:23])=[O:22])[O:16][CH2:15][CH2:14]1)=[O:27])([CH3:32])([CH3:30])[CH3:31]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 66975633HCID 66975633, compound

Product 1

HCID 66976104HCID 66976104, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 M Aqueous sodium hydroxide solution (0.32 mL) was added dropwise to a solution of tert-butyl (6SR,7RS)-6-(3,4-dichlorophenyl)-7-[(2-ethoxy-2-oxoethoxy)methyl]-1,4-oxazepane-4-carboxylate (150 mg) in ethanol (5 mL), and the mixture was stirred at room temperature for 30 min. Water was added to the reaction mixture, and the mixture was washed with diethyl ether. The obtained aqueous layer was neutralized with 1 M hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound.

Workup

  1. washthe mixture was washed with diethyl ether
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-de3f4ffb721f4bd9bd4097f051c9be45
Source dataset
uspto-grants-2014_05
Patent number
US08722662B2

Reaction notes

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