Hydrochloric Acid → HCID 57646935, compound

HRID 1022885Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([O:15][C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][CH:25]=3)[CH:22]=[N:21][CH:20]=[CH:19]4)[CH2:11][CH2:10]2)=[CH:4][C:3]=1[S:26]([N:29]=CN(C)C)(=[O:28])=[O:27].[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:10][CH2:11][CH:12]([O:15][C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][CH:25]=3)[CH:22]=[N:21][CH:20]=[CH:19]4)[CH2:13][CH2:14]2)=[CH:4][C:3]=1[S:26]([NH2:29])(=[O:28])=[O:27]

Participants

Conditions

Temperature: 60 °C

Procedure

133 mg (0.27 mmol) of 2-Chloro-N-dimethylaminomethylene-5-[4-(isoquinolin-6-yloxy)-piperidin-1-ylmethyl]-benzenesulfonamide (169) were dissolved in ethanol. After adding 50 ml of 2N NaOH, the solution was heated to 60° C. for 6 h. After cooling to room temperature, the mixture was neutralized by addition of aqueous HCl and the solvent was removed i. vac. The residue was stirred with ethanol, the inorganic salts were filtered off and the filtrate was evaporated. Rt=0.78 min (Method #2), Detected mass: 432.1 (M+H+).

Workup

temperatureAfter cooling to room temperature
customthe solvent was removed i
filtrationthe inorganic salts were filtered off
customthe filtrate was evaporated

Sources & evidence

ORD record: ord-7d2f5d8403d643439993df8a9b476746
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722671B2

Reaction notes

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